Dolo 650 Tablet: Complete Guide (2026)

Last reviewed by Komal Sharma, Registered Pharmacist · Rajdhani Medicos · Drug License RLF21DL2025003179

Dolo 650 is the most prescribed and most searched medicine in India. During the COVID-19 pandemic, India consumed over 35 crore Dolo 650 tablets in a single year — making it the country's most trusted fever and pain medicine. This guide covers everything you need to know about Dolo 650 in 2026: uses, dosage, side effects, precautions, and where to buy it safely.

What is Dolo 650?

Dolo 650 is a paracetamol tablet manufactured by Micro Labs, with each tablet containing 650 mg of paracetamol (also called acetaminophen). It belongs to a class of medicines called analgesics (pain relievers) and antipyretics (fever reducers).

Key facts:

• Active ingredient: Paracetamol 650 mg
• Manufacturer: Micro Labs Ltd
• Pack size: Strip of 15 tablets
• Price in India: ₹30-35 per strip (MRP varies)
• Schedule: OTC (Over the Counter)
• Prescription: Not required for purchase

Uses of Dolo 650 — What is it prescribed for?

Dolo 650 is prescribed by doctors across India for:

1. Fever

Dolo 650 works on the temperature-regulating part of the brain (hypothalamus) to bring down high fever caused by:

• Viral infections (flu, common cold)
• Bacterial infections
• Post-vaccination fever
• Dengue, malaria, typhoid (as supportive treatment)

2. Mild to moderate pain

• Headache, migraine
• Toothache
• Menstrual cramps (dysmenorrhea)
• Back pain, muscle pain
• Joint pain (mild)
• Post-surgical pain (mild)

3. After vaccination

Many doctors recommend Dolo 650 to manage fever or arm pain after vaccines (COVID-19, flu shots, etc.).

Dolo 650 Dosage — How much to take?

Always follow your doctor's prescription. General dosage guidelines:

Adults (18+ years)

• 1 tablet (650 mg) every 4-6 hours as needed
• Maximum: 4 tablets in 24 hours (2600 mg total)
• Take with or after food to reduce stomach upset
• Swallow with a glass of water

Children (12-18 years)

Use only under doctor supervision. Lower-dose formulations (Crocin 500, Calpol) are usually preferred for younger children.

Special situations

• Empty stomach: Avoid — can cause nausea
• With alcohol: Strictly avoid — risk of liver damage
• Pregnancy: Generally considered safe; consult your gynecologist
• Breastfeeding: Safe at recommended doses

Dolo 650 Side Effects

Most people tolerate Dolo 650 well. However, watch for:

Common (mild)

• Nausea
• Stomach pain
• Loss of appetite
• Mild rash

Rare but serious (seek immediate medical help)

• Skin reaction (Stevens-Johnson syndrome)
• Liver damage (especially with overdose or alcohol)
• Allergic reaction (swelling of face, throat, difficulty breathing)
• Dark urine, yellow eyes (signs of liver issue)

Call our pharmacist at +91 7982544355 if you experience any unusual symptoms.

Dolo 650 vs Crocin: Which is better?

Both contain paracetamol, but differ in strength:

Verdict: Both are equally effective. Dolo 650 has slightly higher dose per tablet, so fewer tablets needed daily. Many Indian doctors prefer Dolo 650 for adults.

Precautions Before Taking Dolo 650

Do NOT take Dolo 650 if you:

• Have severe liver disease
• Drink alcohol regularly (>3 drinks/day)
• Have allergy to paracetamol
• Are taking other paracetamol-containing medicines (combination drugs)

Be cautious if you have:

• Kidney disease
• G6PD deficiency
• Are on blood thinners (warfarin)

Never exceed 4 tablets in 24 hours — paracetamol overdose is the leading cause of acute liver failure in India.

How to Store Dolo 650

• Store below 30°C in a dry place
• Keep away from direct sunlight
• Keep out of reach of children
• Check expiry date before use
• Do not use if strip is damaged or tablets look discolored

Buy Dolo 650 Online in Delhi NCR

Rajdhani Medicos delivers genuine Dolo 650 tablets with verified batch numbers across Delhi NCR including:

• South Delhi — Sarita Vihar, Okhla, Jamia Nagar, Friends Colony, New Friends Colony
• West Delhi — Dwarka, Janakpuri, Rajouri Garden, Tilak Nagar
• East Delhi — Mayur Vihar, Patparganj, Preet Vihar, Laxmi Nagar
• North Delhi — Civil Lines, Model Town, Pitampura
• NCR — Noida, Gurgaon, Faridabad, Ghaziabad

Same-day delivery available within 10 km of our store. Free delivery on orders above ₹499.

Order Dolo 650 Now →

Frequently Asked Questions

Is Dolo 650 safe for daily use?

No. Dolo 650 should only be taken when needed for fever or pain, not as a daily medicine. Long-term daily use can damage the liver and kidneys.

Can I take Dolo 650 with food?

Yes — taking it with or after food is recommended to reduce stomach upset. It works equally well with food.

How long does Dolo 650 take to work?

Usually 30-45 minutes after taking it. Effects last 4-6 hours.

Can I take Dolo 650 during pregnancy?

Paracetamol is generally considered the safest pain reliever in pregnancy. However, always consult your gynecologist before starting any medicine.

Is Dolo 650 banned in India?

No, Dolo 650 is not banned. It is a widely prescribed, regulated OTC medicine.

Can I give Dolo 650 to children?

No. Dolo 650 is for adults. For children, use Calpol or Crocin (lower dose formulations) under doctor guidance.

What if I miss a dose?

If you forget a dose, take it when you remember. Skip if it's close to your next dose. Never take 2 doses at once.

Where can I buy Dolo 650 near me in Delhi?

Rajdhani Medicos delivers Dolo 650 across Delhi NCR within 30 minutes (same-day) for orders within 10 km of Sarita Vihar. Order online here.

When to See a Doctor

Visit a doctor or call us at +91 7982544355 if:

• Fever persists for more than 3 days
• Pain is severe or worsening
• You develop rash, swelling, or breathing difficulty
• You suspect an overdose
• You have liver or kidney disease

Disclaimer: This article is for informational purposes only and should not replace professional medical advice. Always consult a qualified doctor before starting any medication. Dosage and precautions may vary based on individual health conditions.

About the reviewer: Komal Sharma is a Registered Pharmacist with the Delhi Pharmacy Council, and the consulting pharmacist for Rajdhani Medicos.

Rajdhani Medicos — Licensed online pharmacy serving Delhi NCR. Drug License RLF21DL2025003179. GSTIN 07KXQPK3422R1ZJ.